Nonetheless, it has been proven that some ADRs are associated with different receptor properties, for example, 5-HT2 receptors are potentially related to the pathogenesis of valvular heart disorders [9]; Meanwhile, stimulation of alpha-2 adrenergic receptors increases the occurrence of dyskinesias, while alpha-2 adrenergic antagonists have been shown to reduce levodopa-induced dyskinesias [10]. The gene discussed is HTR2A; the disease is heart valve disorder.