Likewise, c-KIT knockdown failed to affect phospho-LYN levels in three human c-KIT-positive breast cancer cell lines with low BRCA1 levels: HCC38 (BRCA1 silenced by methylation), HCC1806, and MDA-MB-157 (BRCA1 low due to downregulation by microRNA [miRNA]) (Garcia et al., 2011, Li et al., 2013) (Figure S3A). The gene discussed is BRCA1; the disease is breast cancer.