BRCA1 and breast carcinoma: Although c-Kit is highly expressed in Brca1 mutant mammary tumors (Regan et al., 2012, Smart et al., 2011), as well as in a subset of breast cancers within the TNBC group (Jansson et al., 2014), targeting this receptor has not been an effective therapeutic approach (Yardley et al., 2009).