We and others have previously reported that neurons generated from iPSCs with genetic forms of AD recapitulate aspects of the disease, including increased Aβ peptide production in trisomy 21 and APP duplication neurons (Moore et al., 2015, Israel et al., 2012) and increased production of longer forms of Aβ in PSEN1 and APP mutant neurons (Moore et al., 2015, Muratore et al., 2014, Woodruff et al., 2016, Israel et al., 2012). Here, PSEN1 is linked to Alzheimer disease.