JAM3 and neoplasm: Although the direct consequences of JAM-C downregulation in tumor-draining LN LECs are difficult to estimate, previous findings suggest that lower JAM-C levels lead to decreased vessel permeability, decreased leukocyte trafficking in the LN, and possibly decreased interaction with metastasizing tumor cells (Fuse et al., 2007, Santoso et al., 2005, Weber et al., 2007).