Stainings of LN sections for LYVE-1, Prox1, and the proliferation marker Ki67 confirmed that the LEC proliferation rate was increased both in the subcapsular sinus and the medullary sinus of 4T1 tumor-draining, but not non-draining, LNs (Figures 1E, 1F, S2C, and S2D). The gene discussed is PROX1; the disease is neoplasm.