To study the effects of disrupting the RAS-PI3K interaction in EGFR-mutant driven lung cancer, we used the conditional RAS-binding-domain-mutant p110α mouse model previously described, which has one RBD-mutant allele of Pik3ca (T208D plus K227A, referred to here as Pik3caMUT) and one floxed, inducibly deletable allele (Pik3caFlox), along with a tamoxifen-activatable ubiquitously expressed Cre recombinase, ROSA26-CreERT2 (Castellano et al., 2013, Murillo et al., 2014). Here, EGFR is linked to lung cancer.