EGFR and lung cancer: To determine whether impairing the interaction of RAS with PI3K p110α can affect the in vivo growth of human EGFR-mutant lung cancer cells in a tumor cell-autonomous manner, we tested the ability of the PC9 and H1975 cell lines described above to form subcutaneous tumors in immunodeficient mice using luciferase expression to monitor tumor growth using bioluminescence.