HDAC4 and cancer: The following examples have been reported: miR-1 inhibits cancer cell growth through the downregulation of oncogenes and/or transcription factors, including Met, HDAC4, PIM1, and Slug [9]; miR-21 induces myoblast apoptosis, which leads to cancer cachexia in patients with Toll-like receptor 7 [25]; miR-34a-5p controls cell proliferation through the modulation of the E2F signaling pathway [11]; miR-125a-3p suppresses cell proliferation and migration by targeting Fyn [12]; and miR-221-5p, which has the same seed sequence as miR-8073, inhibits cancer cell proliferation [14].