However, hippocampal expression of glucocorticoid receptor (GR) mRNA was increased in OVX-HF mice compared with control mice (P<0.05), while its expression was decreased in the E2-SC group (P<0.01) and the E2-ICV group (P<0.05) compared with the OVX-HF group (Fig 6B). Here, NR3C1 is linked to hydrops fetalis.