In CIN, the mutation frequency of CHEK1, EI24, LOH11CR2A, RASSF1A, PTCH1, and PIK3CA is 28%, 21% 107, 15% 107, 26% 108, 1.5% 97, and 2.4% 105, respectively. Here, PTCH1 is linked to cervical squamous intraepithelial neoplasia.