It is well‐known that VEGFR2 plays a vital role in tumour angiogenesis and metastasis.27 EphrinB2, which is expressed in cancer cells, was proven to be involved in VEGF/VEGFR mediated angiogenesis.28 We address this issue by examining the correlation between the expression of EphrinB2 and the progression of liver cancer. This evidence concerns the gene EFNB2 and neoplasm.