EphrinB2 promotes VEGFR endocytosis in endothelial cells and enhances VEGF‐mediated angiogenesis.5, 6 Regulation of VEGFR signalling in cancer cells further results in the activation of PI3K/AKT and MAPK/ERK pathways which regulate cell proliferation, migration, and angiogenesis. This evidence concerns the gene VEGFA and cancer.