EphrinB2 promotes VEGFR endocytosis in endothelial cells, thereby enhancing VEGF‐mediated angiogenesis,32 which is essential in normal and pathological situations.33 It has been implicated in mediating angiogenesis signalling in human cancer cells by promoting the internalization of VEGFR2 and VEGFR3, which in turn are linked to downstream effectors involved in PI3K/AKT/mTOR and ERK/MAPK pathways.34, 35 The proteins selected by phosphor‐antibody array were confirmed by western blot. This evidence concerns the gene AKT1 and cancer.