Angiogenesis is critical for re‐establishing the blood supply to the surviving myocardium after MI and, consequently, to the recovery of cardiac function.25 To test whether this model is suitable for studying angiogenesis, we detected the angiogenesis by analysis of CD31, which is a biomarker for endothelial cells.26 As shown in Figure 6A, ischaemia dramatically induced angiogenesis in mice with MI caused by both traditional method and new method, suggesting this new method is suitable for studying in ischaemia‐induced angiogenesis. The gene discussed is PECAM1; the disease is myocardial infarction.