Two proteins at the parasite-host interface, the up-regulated in infective sporozoites gene 4 (UIS4) and the exported protein-1 (EXP-1), located at the site of the parasitophorous vacuole membrane (PVM), have indeed been shown to interact with host cell proteins in rodent malaria models (Sá E Cunha et al., 2017; Mueller et al., 2005; Petersen et al., 2017). This evidence concerns the gene XPO1 and malaria.