TLR4 and liver disorder: More specifically, the ketone metabolite β‐hydroxybutyrate blocked NLRP3 inflammasome‐mediated reactions.22 Meanwhile, toll‐like receptor 4 (TLR‐4) activation is implicated to play a key role in both inflammatory and fibrogenic pathways, thus contributing to liver disorders and complications of liver cirrhosis.23 However, though gut‐liver axis, TRF demonstrated its effect of down‐regulation of TLR‐4 level.