The colocalization of the plasminogen activators and plasminogen driven by AIIt could increase the cleavage of plasminogen into plasmin, which further activates pro‐MMPs (matrix MMPs) into active MMPs.12, 28, 29, 30 Previous studies have revealed that plasmin and MMPs could function as carcinogenic factors by enhancing the proliferation and metastasis of various tumours, including HCC.31, 32, 33, 34 Next, to explore alterations in the expression of plasmin and MMP proteins caused by LUCAT1, ELISAs were conducted. This evidence concerns the gene PLG and hepatocellular carcinoma.