AQP6 and kidney disorder: Knockouts of several genes described in this study with previously unreported ocular phenotypes were found to have coexisting kidney disease: Aqp6, Dnase1l2, Efna5, Fgf7, and Galk2. Comprehensive phenotyping of all organ systems as performed by the IMPC may provide many other multi-systemic disease associations and useful insights for understanding and treating human disease, including but not limited to identifying pathways involed in disease progression, identification of biomarker candidates for disease analysis, and surrogate measures for therapeutic testing.