Interestingly, EEF1A2 has been reported to be overexpressed in multiple cancer types, including breast cancer and liver cancer57,58, while our analyses showed that EEF1A2 is up-regulated in six cancer types, but strikingly down-regulated in four cancer types, namely COAD, esophageal carcinoma, head and neck squamous cell carcinoma, and stomach adenocarcinoma, suggesting a potential controversial function of EEF1A2 in these cancer types. This evidence concerns the gene EEF1A2 and head and neck squamous cell carcinoma.