IGHE and atopic eczema: Therefore, we suspect that these growth alterations might influence thymus development, resulting in a diminished population of T helper (Th) 1 lymphocytes, favoring Th2 populations and consequently raised serum IgE,35 an immune reaction that is seen in atopic eczema and other atopic conditions.36 However, the exact mechanisms responsible for the association of altered fetal growth with development of atopic eczema are unknown, the observation points to involvement of periconception or early pregnancy factors in the etiology of infantile atopic eczema.