Compared with non-responders, responders show a trend to employ lower peripheral CD4+, CD8+, CD25+Foxp3+Treg and Gr-1+CD11b+MDSC cell density, higher CD8+ to Treg ratio, and similar PD-1+ fraction at day 10 (Fig. 2), which is consistent with the trend within tumour tissue except CD8+ cells (Fig. S1). Here, CD4 is linked to neoplasm.