Accumulating evidence suggest that autophagy is altered by many cancer therapies including antimetabolites, paclitaxel, etoposide, vinblastine, NF-κB inhibitors, tyrosine kinase inhibitors, COX-2 inhibitors, estrogen signaling antagonists, angiogenesis inhibitors, DNA damaging agents and alkylating agents [37,38]. Here, NFKB1 is linked to cancer.