Overall, the biological importance of the UBA domain is highlighted by the finding that DCNL1 is frequently amplified and/or mutated in various tumors, including lung and squamous cell carcinomas (hence DCNL1's alternative name squamous cell carcinoma-related oncogene, SCCRO) (31, 46, 47). This evidence concerns the gene DCUN1D1 and squamous cell carcinoma.