Now, we can exclude this possibility also in morbid obesity, being this the first study evaluating exercise-induced secretion of GH isoforms in an obese population and demonstrating a ratio of circulating levels of 22 kDa- to 20 kDa-GH similar to that of normal-weight individuals (i.e., about 10–15) [28]. Here, GH1 is linked to morbid obesity.