CD8A and neoplasm: Interestingly, lower doses of AZD8835 (25 mg/kg BID intermittently) were not sufficient to drive strong anti-tumor response in the CT-26 model (Additional file 3: Figure S2A-B), despite reduced tumor T-regs frequencies and shifted CD8/T-regs ratios (Additional file 3: Figure S2C-D), underscoring how critical optimised dose and schedule is for efficacy.