We hypothesized that (1) a high-intensity interval-based training program would improve skeletal muscle remodeling reflected by reductions in remodeling markers: muscle inflammatory cytokines, myostatin, and plasma galectin-3; (2) changes in remodeling markers would be associated with improvements in clinical measures of body composition (goal to increase lean mass and decrease body fat) and cardiopulmonary fitness; and (3) remodeling markers and clinical associations in subjects with RA would differ from those in subjects with prediabetes. Here, MSTN is linked to prediabetes syndrome.