IL6 and cancer: This case report supports the use of anti-IL-6 therapy in complicated irAEs with unsatisfactory response to steroids as well as the rationale to use the predominant type of immune infiltrate on the biopsy (in this case T cells) as a biomarker to personalize treatment in steroid-refractory irAEs as we had just proposed in our recent therapeutic personalized algorithm based on selective inhibition of key inflammatory components involved in the pathophysiological processes of irAE without compromising cancer immunotherapy efficiency [25].