Pathway analysis indicated that 87 pathways corresponded to up-regulated transcripts and up-regulated genes were mainly related to cytokine–cytokine receptor interaction, osteoclast differentiation, cell adhesion molecules (CAMs), PI3K-Akt signaling pathway and focal adhesion, while down-regulated DEGs were associated with Fanconi anemia pathway, mismatch repair, spliceosome, DNA replication and cell cycle (Fig. 3c, d). Here, AKT1 is linked to Fanconi anemia.