In addition, the mRNA levels of Grp78 and CHOP were significantly increased in the diabetes group, compared with the controls (P < 0.05, Fig. 4f); whereas treatment with Danshen injection for 6 weeks could effectively decrease the expression levels of Grp78 and CHOP (P < 0.05 vs. the diabetes group, Fig. 4f). The gene discussed is HSPA5; the disease is diabetes mellitus.