Klameth et al. established 5 CTC cell lines from patients with recurrent small cell lung cancer (SCLC) that developed tumorospheres spontaneously and showed the typical markers associated with SCLC, such as synaptophysin, enolase-2 and chromogranin A, as well as high resistance to the chemotherapeutics commonly used in the treatment of SCLC. The gene discussed is ENO2; the disease is small cell lung carcinoma.