TP53 and lung cancer: However, TNFAIP8-v2 knockdown increased the expression and binding of p53 to its target genes such as CDKN1A, GADD45A, RRM2B, and others, leading to increased expression of p21, cell cycle arrest, and doxorubicin-mediated DNA damage, clearly suggesting that TNFAIP8 controls p53 function and regulates lung cancer cell progression [18].