In hepatocellular carcinoma, TNFAIP8 interacts with large tumor suppressor kinase 1 (LATS1), a serine/threonine-protein kinase, and overexpression of TNFAIP8 inhibits Yes-associated protein (YAP) phosphorylation, resulting in nuclear localization and stabilization of YAP. Here, LATS1 is linked to hepatocellular carcinoma.