In esophageal squamous cell carcinoma (ESCC), overexpression of TNFAIP8 was found in 59.8% tumor specimens, and the 3-year lymphatic metastatic recurrence rate among TNFAIP8-overexpressing patients was significantly higher than in TNFAIP8 lower-expressing patients or TNFAIP8-negative patients [78]. The gene discussed is TNFAIP8; the disease is esophageal squamous cell carcinoma.