The clinical relevance of TNFAIP8 was also determined in esophageal squamous cell carcinoma: higher expression of TNFAIP8 co-relates with TNM stage, tumor depth, lymph node metastasis, distant metastasis, lymphatic invasion, and venous invasion among ESCC patients, as well as with poor survival [79]. This evidence concerns the gene TNFAIP8 and neoplasm.