Systemically administered liposome-entrapped TNFAIP8 antisense oligonucleotide (LE-AS5) decreases TNFAIP8 expression in PC3 prostate tumor-bearing athymic mice, which leads to tumor growth when mice were exposed to radiation or anticancer drug, docetaxel, suggesting that, TNFAIP8 may modulate radiation or drug-mediated resistance in prostate tumors [22]. The gene discussed is TNFAIP8; the disease is prostate neoplasm.