Previously, we demonstrated that antisense oligonucleotide-mediated inhibition of endogenous TNFAIP8 decreases expression of VEGF receptor-2 in tumor cells and in human normal lung microvascular endothelial cells (HMVEC-L), and inactivation of TNFAIP8 decreases the expression of metastasis-related molecules MMP-1 and MMP-9, suggesting that TNFAIP8 plays an important role in lung cancer tumor progression [68]. This evidence concerns the gene MMP1 and neoplasm.