Ectopic overexpression of TIPE1 in lung cancer cells reduces cell colony formation and proliferation and induces apoptosis by regulation of cyclin D1, cyclin B1, caspase 8, caspase3, matrix metallopeptidase 2 (MMP2), and matrix metallopeptidase 9 (MMP9) expression. The gene discussed is MMP2; the disease is lung cancer.