Fig 3B illustrates an enrichment plot for TNFα signaling via NFKβ, a pathway involved in inflammation. In addition, enrichment of an angiogenesis pathway was also found in subjects with classic A-T, supporting a previous study that reported an association between presence of telangiectasias and ATM deficiency. [26] Enrichment plots for the top 15 processes are included in S1 Fig. This evidence concerns the gene TNF and telangiectasis.