CXCL8 and colorectal cancer: [4] [5] [6] Upregulation of the pro-inflammatory cytokines, IL6 and IL8 have been associated with the SASP phenotype.[7] IL6 has been associated with poorer cancer outcomes [8] while elevated levels of serum IL8 have been associated with colorectal cancer.[9] We previously reported on a subset of children and adults with A-T who had elevated serum levels of IL6 and IL8.