In Fig 1, we present a comprehensive representation of all previously reported structural variants found in CNTNAP2 in psychiatric disorders such as ASD or ID [13, 29–38], schizophrenia or bipolar disorder [51–54, 78], ADHD [55], neurologic disorders such as epilepsy, Tourette syndrome or Charcot-Marie-Tooth [56–61]; and finally language-related phenotypes such as speech delay, childhood apraxia of speech and dyslexia [62–65]. This evidence concerns the gene CNTNAP2 and nervous system disorder.