CNTNAP2 and cortical dysplasia-focal epilepsy syndrome: The crucial role of CNTNAP2 in the human brain became clear in 2006 when Strauss et al, reported homozygous mutations in Old Order Amish families segregating with a severe Mendelian condition, described as cortical dysplasia-focal epilepsy (CDFE) syndrome (OMIM 610042) [5].