Even though liver is the major reservoir supporting viral replication, the sites of insulin resistance in CHC have been debated in the published literature.6, 8 Some studies have suggested that the liver is the major site of insulin resistance6, 7 whilst others have implicated adipose tissue and skeletal muscle.8 The mechanisms underlying the crosstalk between liver and extra‐hepatic sites also remain largely unknown. Here, INS is linked to cryohydrocytosis.