Comparison between a mixed gender CHC cohort and a purely male control cohort may have underestimated the degree of insulin resistance in the CHC group, as male subjects are perceived to have higher insulin resistance due to the greater amounts of visceral and hepatic adipose tissue, and lack the protective effect of oestrogen.39 The number of participants is small making it difficult to extrapolate the relevance of observed metabolic perturbation in patients with CHC or the subsequent improvements in tissue‐specific insulin sensitivity after treatment. The gene discussed is INS; the disease is cryohydrocytosis.