PPARG and obesity due to melanocortin 4 receptor deficiency: Obesity is a significant risk factor for many life‐threatening diseases, such as type II diabetes, hypertension, cardiovascular and cerebrovascular disease, and its global impact on health is enormous.1 Obesity can begin as a simple overstorage of unmetabolized energy in the adipose tissue of individuals whose caloric intake exceeds the energy combustion capability of peroxisome proliferator‐activated receptor‐(PPAR)‐mediated fatty acid oxidation systems.2 Furthermore, adipogenesis is driven by the activation of a cascade of genes, especially PPARγ.3, 4