In rat models, exosomes from hucMSC can alleviate T2DM through reversing peripheral insulin resistance and relieving β‐cell destruction.37 Endogenous annexin A1 (ANXA1) is released as a component of EVs derived from intestinal epithelial cells, and these ANXA1‐containing EVs activated wound repair circuits.38 Here, ANXA1 is linked to type 2 diabetes mellitus.