For example, activated Kupffer cells could aggravate liver injury and fibrosis by producing ROS and tumour necrosis factor‐α via the My88 and TRIF pathways.29, 30 On the other hand, Kupffer cells ameliorate liver damage by secreting the hepatoprotective cytokine IL‐6 and the anti‐inflammatory factor IL‐10.5 Intrahepatic NK cells in patients with ALD could kill activated HSCs and suppress liver fibrosis.31 Invariant NK T cells also inhibit the number and function of NK cells by producing IL‐10.32 More recent studies have shown that adaptive immune cells are also involved in ALD. This evidence concerns the gene IL6 and Hepatic fibrosis.