In a rodent model of uncontrolled insulin‐deficient diabetes, Meek and colleagues report that infusion of BDNF to either the lateral cerebral ventricle or the VMH attenuates diabetic hyperglycemia via an insulin‐independent inhibition of hepatic glucose production (Meek et al., 2013). The gene discussed is BDNF; the disease is hyperinsulinemic hypoglycemia, familial, 4.