TNF and familial dilated cardiomyopathy: For example, IL1α, TNF‐α, and C1q (found in DCM, see Figure 6) induce the neurotoxic A1 astrocyte phenotype (Liddelow et al., 2017) suggesting that in MC‐Demy this astrocyte phenotype may be affecting remyelination, as previously reported (Nash et al., 2011).