LGALS3 and ovarian clear cell cancer: Similar to our data, downregulation of galectin-3 by siRNA in ovarian clear cell carcinoma [21] and osteosarcoma (to approximately 33%) [10] did not affect proliferation and apoptosis of cancer cells; however, in combination with cisplatin, it increased the extent of apoptosis [10, 21] and inhibited proliferation [21].