However, additional functions related to tumor progression and metastasis development (Qin et al., 2008[29]; Wang et al., 2013[37]), such as metalloproteinases expression (Qin et al., 2008[29]), cell migration and epithelial-mesenchymal transition (EMT) (Tomar and Schlaepfer, 2010[33]; Wang et al., 2013[37]) have also been described and attributed to the RAC3 splicing variant Delta 4-SRC3 (Long et al., 2010[21]). Here, RAC3 is linked to neoplasm.