RAC3 and cancer: Although the effect of RAC3 overexpression in non-tumoral cells has not been deeply investigated up to date, we have previously demonstrated that RAC3 overexpression as a unique change, in the non-tumoral human embryonic kidney cell line (HEK293) gives to these cells the ability to grow in soft agar forming colonies (Rubio et al., 2012[30]) and to induce cancer stem cells (CSC) (Panelo et al., 2018[25]).