In fact, RAC3 is an oncogene that contributes to tumor development acting as a nuclear receptor coactivator of several transcription factors (Liao et al., 2002[19]; Wang et al., 2013[37]; Yan et al., 2006[41]) that control the expression of genes related to cell cycle and proliferation (Louie et al., 2006[22]; Planas-Silva et al., 2001[28]; Rubio et al., 2006[31]; Torres-Arzayus et al., 2004[34]; Zhou et al., 2003[42]), inhibition of apoptosis (Colo et al., 2007[5], 2008[6])) and autophagy (Fernandez Larrosa et al., 2012[11]). Here, RAC3 is linked to neoplasm.