AEs of interest included increased blood CPK (77%; Grade  ≥  3 12%), decreased ejection fraction (38%; Grade  ≥ 3 4%), retinal detachment (31%; no Grade  ≥  3), macular detachment (27%; no Grade  ≥  3), thrombocytopenia (19%; Grade  ≥  3 15%) and increased troponin T (19%; no Grade  ≥  3). Here, PIK3C2A is linked to retinal detachment.