AKT1 and head and neck squamous cell carcinoma: We previously reported that EGFR activated the IKK/NF-κB pathway through mTORC1 downstream of PI3K/Akt in both cisplatin-sensitive and cisplatin-resistant HNSCC cells.25 Here, we examine the role of IKK/NF-κB in the regulation of HNSCC cell sensitivity to EGFR inhibitors, including Gefitinib and Erlotinib, in multiple HNSCC cell lines in vitro and in vivo.