It has been well documented that NF-κB confers sensitivity of HNSCC tumours to radiotherapy and has a direct association with patient prognosis.44–46 We would like to determine whether radiotherapy induces IKKβ kinase activity and whether CmpdA-induced inhibition of IKKβ improves the efficacy of radiotherapy in HNSCC. Here, NFKB1 is linked to neoplasm.