PTEN and glioblastoma: Similarly, the extensive analysis of driver genes involved in GBM progression resulted in identification of several recurrent mutations either common or subtype-specific, including mutant TERT promoter, IDH1 gene, EGFR (including EGFRvIII deletion mutant), PDGFRA, PTEN, TP53, CDKN2A/B, ATRX and several others [2].