VEGFA and neoplasm: There was also induction of poly (ADP-ribose) polymerases (PARP) cleavage, increase in the protein expression of Bax with decrease in Bcl-2, activation of caspases and decrease in Ki-67, proliferating cell nuclear antigen (PCNA), CD-31 and vascular endothelial growth factor (VEGF) in tumor tissues of mice treated with Chit-nanoEGCG, as compared with groups treated with EGCG and control group [41].