TP53 and posterior cortical atrophy: There was dose- and time-dependent inhibition of class I HDACs (HDAC1, 2, 3 and 8) on treatment of PCa cells with GTP (2.5–10 μg/mL) and EGCG (5–20 μM), while loss of p53 acetylation at both the sites was observed on withdrawal of treatment with GTP/EGCG.