Myositis-associated autoantibodies include anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), anti-cytosolic 50-nucleotidase 1A, anti-Mi-2 nuclear antigen, anti-transcriptional intermediary factor 1-g (TIF-1g), anti-melanoma differentiation-associated gene 5, anti-small ubiquitin-like modifier activating enzyme, anti-nuclear matrix protein 2, anti-Jo1-histidyletransfer RNA synthetase, and anti-signal recognition particle [38]. Here, HMGCR is linked to myositis disease.