Yet, in the context of anti‐tumour therapy, using a mouse model of colon carcinoma, Brackett and colleagues demonstrated that photodynamic therapy (PDT) was also associated with the rapid recruitment of neutrophils (i.e. within 4 h post PDT) into tumour‐draining LNs through HEVs in an IL‐17 and CXCR2/CXCL2 (but not CXCL1)‐dependent manner 58, 107.The authors also showed the importance of L‐selectin and of peripheral node addressin (PNAd) in neutrophil entry through HEVs in this model. This evidence concerns the gene CXCL1 and neoplasm.