In plasma samples obtained in 150 stable HD patients (92 men) aged 40–70 years, levels of sclerostin, fibroblast growth factor (cFGF23), osteocalcin, the N-terminal propeptide of type I procollagen, C-terminal telopeptide of the alpha chain of type I collagen (β-CTx), and inflammatory markers (IL-6 and TNF-α) in addition to routine parameters (calcium, phosphorus, parathyroid hormone—iPTH, 25-OH-D, alkaline phosphatase) were measured. Here, SOST is linked to Huntington disease.