Rand and colleagues [54] analyzed 5-hydroxytryptamine receptor 1A (HTR1A), orthopedia (OTP), and Adenylate Cyclase Activating Polypeptide 1 (ADCYAP1, formerly PACAP) genes which are involved in the embryologic development of the hypothalamus and autonomic nervous system in a set of 25 ROHHAD patients and 25 matched controls. The gene discussed is OTP; the disease is rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome.