Besides, lipid contents in livers obtained from STZ-induced diabetic AdIL-4 mice (diabetes with transient IL-4 overexpression) and HFD + IL-4 mice (obesity-induced insulin resistant status with long-term IL-4 overexpression) [22] were immunohistochemically analyzed. The gene discussed is IL4; the disease is obesity due to melanocortin 4 receptor deficiency.