For example, short-term activation of JNK may increase the viability and growth of pancreatic cancer cells [25, 26, 47], whereas long period of activation may result in cell apoptosis such as through the E3 ubiquitin ligase ITCH-induced c-FLIPL turnover [24, 27, 28, 48]. The gene discussed is CFLAR; the disease is familial pancreatic carcinoma.