MMP9 and neoplasm: Resveratrol is a specific inhibitor of NF-ҡB in different tumor cells [21]; it can downregulate the nuclear localization of NF-ҡB phosphorylation and its acetylation, which cause attenuation of NF-ҡB-regulated gene products (MMP-9, CXCR4) involved in tumor-invasion and metastasis [22].