TF and Tangier disease: The iron metabolism is regulated by many factors such as hepcidin, which is peptide hormone that affects iron absorption in small intestine and systemic iron regulation [3]; transferrin (Tf) that bind iron at physiological iron concentrations and nontransferrin bound iron (NTBI) in iron overload concentrations [4]; serum ferritin (SF) and Hemosiderin that reflect the total body iron stores and act as indicative of iron overload [1].