The levels of CA 19-9 for use for the detection of pancreatic cancer were associated with higher sensitivity (ratio of sensitivity: 1.54; 1.31–1.81; P < 0.001), DOR (DOR: 3.50; 95% CI: 2.24–5.45; P < 0.001), and AUC (ratio of AUC: 1.24; 95% CI: 1.15–1.33; P < 0.001) compared with the variable CEA, while no significant difference between CA 19-9 and CEA was noted with regard to specificity (ratio of specificity: 0.97; 95% CI: 0.89–1.06; P = 0.517). Here, CEACAM5 is linked to pancreatic neoplasm.